1win collagen12/11/2023 ![]() ![]() It is present in scar tissue, the end product when tissue heals by repair, as well as tendons, ligaments, the endomysium of myofibrils, the organic part of bone, the dermis, the dentin, and organ capsules. Īs mentioned Type 1 collagen can be found in a myriad of different places in the body, mainly forming the matrix of connective tissues. Homotrimers in particular playing an important role in wound healing, however heterotrimers are the dominant isoform found in the body. Collagen can also be found in two different isoforms, either as a homotrimer or a heterotrimer, which both can be found during different periods of development. The Col I gene itself takes up a triple-helical conformation due to its Glycine-X-Y structure, x and y being any type of amino acid. Collagen I itself is created by the combination of both a proalpha1 and a proalpha2 chain created by the COL1alpha1 and COL1alpha2 genes respectively. Type I forms large, eosinophilic fibers known as collagen fibers, which make up most of the rope-like dense connective tissue in the body. Due to this, it is also the most abundant protein type found in all vertebrates. Type I collagen is the most abundant collagen of the human body, consisting of around 90% of the body's total collagen in vertebrates. Type of connective tissue in animals collagen, type I, alpha 1
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